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ideas for drug-resistant adult?

I have adult ADD and it is interrupting work and home.  I’m self employed but nonproductive.

Ritalin, Adderal and Concerta had no effect.  But neither does tylenol, dental injectables, Demerol, or even Morphine. Nor does alcohol or THC!  I’m not just talking about ADD: I can’t get drunk or stoned, and they dont kill pain either. Drugs just don’t work on me at all. 

The doc wants me to try Strattera, but its expensive and since drugs in general don’t work on me, I’m reticent to try. 

I’d like to try non drug methods, or even a drug if it would actually do something…  even thought about acupuncture.  Omega oils didn’t help after a long trial, and flaxseed tastes like…

But I’ve got do SOMETHING !

Any recommendations? Anyone out there have this same situation?



How interesting! I clicked on this post because I’ve been through a TON of ADHD drugs-stimulants mostly. I’m good for a few months and then notice a negative change. I don’t have the issue with the other drugs, thank goodness. Can they do surgery on you?

I say try everything you can. Try acupuncture. Try changing your diet. Try away!

Posted by organizationschmorganization on Jun 20, 2014 at 6:46am

It sounds like anxiety to me.

Are you seeing a psychiatrist? GPs are not helpful.

Is there a support group near by?

Posted by DanielB on Jun 20, 2014 at 7:44am

Take a look at this article and see if the profile fits.  (The stimulants are also metabolized by this same pathway—2D6).

Posted by BC on Jun 20, 2014 at 9:40am

BC that sounds exactly like me.  I was clued into this by a surgery nurse, but didn’t know where to find the exact condition.

I wonder if they can test that ‘family’ of my liver and maybe pinpoint some things that DO have a chance of working?  I also wonder how much that will cost….

Posted by Honorable JR on Jun 20, 2014 at 4:54pm

Daniel, you might have been replying to organization… but I don’t have anxiety.  I also don’t find drugs to work for a while, they don’t work at all.  My father was awake through his quadruple bypass (!) so I suspect the 2D6 issue described above. If that does show to be the case for me, then my best bet for treating ADD , AND for ever having any surgery, would be if they could match up a drug that works around my specific liver condition…

Posted by Honorable JR on Jun 20, 2014 at 5:01pm

BC thank you for finding this! I’m going to get tested for cyp-2d6 function.  Perhaps the docs can find an inhibitor or inducer to help my liver function more normally, so I can get help for ADD, and also for pain!  Thank you!

Posted by Honorable JR on Jun 20, 2014 at 5:27pm

Your welcome!  Honestly it was really cool for me to read your post and find a valid USE for all the massive amounts of internet research I’ve done over the last 6 months on the genetic mutations involved in various bad drug reactions.  The tests to diagnose are widely available; here’s a link to just one of the companies that do it.  They’ve got lots of info on their site ( if you’re interested, but you have to click around a while to find it all, including the “for prescribers” section if you’re so inclined.  Here’s a link to “talking to your doctor” about it.

Posted by BC on Jun 21, 2014 at 1:44am

Honorable JR i was replying to you.

you indicated the lack of response to everything. that’s tolerance in some cases. in other instances it’s co-morbidity, whether it’s anxiety or the enzyme defect.

there’s no reason to not get tested, but don’t grasp at straws. the more common problem is more likely.

you indicated that Demerol, morphine, alcohol, amphetamine, marijuana and methylphenidate, all of them, don’t work for you. these all work in wildly different ways. Demerol is a pain relief solution to the enzyme defect.

that’s why i asked if you are seeing a psychiatrist. surgical nurses are not psychiatric nurses. they don’t have similar jobs, even if it seems they might.

being insensate to the effects of all of those substances just doesn’t sound plausible.

i, too, have issues w/ being awake during surgery. although, awake isn’t exactly the word i’d use.

i, too, have issues w/ opioids not working as expected.

i get it.

i really do.

i’ve had had more than one unpleasant occurrence, but you’re putting a blanket on all of everything just to rule other options out. that’s why i suggested anxiety.

no, i’m not a doctor. that’s why i asked if your care provider was specifically trained to help with this particular issue.

the other much more common indication is medication interaction. you left out a lot of details. you’re asking for a direction to take, but you aren’t offering details. self diagnosing is all fine, but you will suffer at the hands of an incompetent physician. i promise.

please, go to someone who is qualified and don’t ask for any definitive opinions on a chat board.

there is help. i promise.

Posted by DanielB on Jun 21, 2014 at 3:04am

Hi, DanielB.  Actually, the info BC provided was exactly what was needed.  I had searched before, but never found what I was looking for.  I am now having the enzyme test arranged at my doctor’s office.  BECAUSE all of the meds that don’t work on me are different, having the enzyme problem answer ALL of them IS the simplest answer.  As to my care provider being specifically trained, I would doubt that very many family physicians have enough experience and training to diagnose this issue.  Frankly, an empowered patient like myself, who is very aware of their body and it’s interactions, is the best clue a doc could have.  BTW, if you are having similar issues, maybe you should check out the link BC gave, too, and go talk with your physician about it…?  Thanks for the input, though!  I’ll try to update as soon as I know something more.

Posted by Honorable JR on Jun 24, 2014 at 2:05am

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